| 产品概述: |
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
|
| 特异性: |
Dok-1 Polyclonal Antibody detects endogenous levels of Dok-1 protein.
|
| 使用方法: |
WB 1:500-2000; IHC 1:100-300; IF 1:200-1000; ELISA 1:5000; Not yet tested in other applications.
|
| 稳定性: |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8°C.
|
| 存储: |
Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving. **Avoid repeated freeze-thaw cycles.**
|
| 存储缓冲液: |
0.01M PBS (pH 7.4) with 0.5% BSA, 50% glycerol and 0.02% sodium azide.
|
| 注意事项: |
This product is for research use only, not for diagnostic or therapeutic use.
|
鄂公网安备 42011102003188号
