DOK6 shares 75% and 78% identity with Dok4 and Dok5, respectively, over the PH and PTB domains and also shares a C-terminal region motif that may distinguish this subclass of DOK proteins. RT-PCR analysis of human tissues detected highest expression in the CNS, especially in fetal brain, and high expression in kidney and testis, as well as several Ret-positive neuroblastoma cell lines. In situ hybridization of mouse embryos detected Dok6 expression in the developing neocortex, diencephalon, and spinal cord, as well as in uteric buds of the developing kidney, and in the cranial parasympathetic, sensory, and sympathetic ganglia and the facial motor nucleus. The distribution of Dok6 developmental expression overlapped with Ret expression.
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