Recombinant Human Endothelial cell-specific molecule 1 (ESM1) Protein

  • Cat.No.: AP50192HU

  • Reactivity: Human

To Purchase AP50192HU

100μg 500μg
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Product Details

生产种属 Human
来源 Prokaryotic expression
宿主 E. coli
同义词 ESM1; endocan
浓度 1 mg/mL
形态 Lyophilized or Liquid
纯度 > 95% as determined by SDS-PAGE
序列 Trp20-Arg184 (Q9NQ30)
标签 N-terminal His-tag
纯化方式 Affinity purification
分子量 19 kDa
应用 Western blotting,ELISA;SDS-PAGE;Antigen;


Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene. This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.


Reconstitute in PBS or others.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.


Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.


Lyophilized from 50mM Tris-HCL,0.5mM EDTA,300mM NaCl,pH 9.0


This product is for research use only, not for diagnostic or therapeutic use.