Parkinson’s disease (PD) involves both mitochondrial dysfunction and Lewy body pathology. However molecular links between these features remain unclear. Here, we identify Presenilin-associated rhomboid-like protein (PARL) as a Lewy body component, RARL regulates mitochondrial apoptosis via interacting with orphan nuclear receptor Nur77.
Product: Human Presenilins-associated rhomboid-like protein, mitochondrial (PARL) ELISA Kit
Pub Date：2025-10-06 IF: 9.600
The incidence of certain types of extrahepatic cancers significantly increases in nonalcoholic fatty liver disease (NAFLD), the mechanisms of which are elusive.
Product: Mouse Receptor tyrosine-protein kinase erbB-4 (ERBB4) ELISA Kit Mouse Mitochondrial ribonuclease P protein 1 (RG9MTD1) ELISA Kit
Pub Date：2025-09-24 IF: 30.900
Triple-negative breast cancer (TNBC) urgently requires new therapeutic strategies due to the limited efficacy of conventional treatments. Recently, PANoptosis, an integrated form of apoptosis, necroptosis, and pyroptosis, has emerged as a promising target in cancer therapy, though effective agents remain scarce.
Product: Human High mobility group protein B1 (HMGB1) ELISA Kit
Pub Date：2025-08-22 IF: 6.600
Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2’s oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT).
Product: Human YEATS domain-containing protein 2 (YEATS2) ELISA Kit
Pub Date：2025-07-29 IF: 3.800
Endophilin A2 (EPA2) is a member of the Endophilin family. The relationship between EPA2 and SLE pathogenesis is unclear.Plasma levels of EPA2 in SLE patients and healthy controls were detected by ELISA, and EPA2 mRNA levels of SLE patients were explored by qRT-PCR. EPA2 siRNA adenovirus was further injected into pristane-induced lupus mice, and the histological and serological changes were observed.
Product: Human Endophilin-A2 (SH3GL1) ELISA Kit
Pub Date：2025-07-01 IF: 2.000
Microvascular invasion (MVI) is a major determinant of poor prognosis in hepatocellular carcinoma (HCC). However, reliable noninvasive biomarkers for the preoperative evaluation and diagnosis of MVI are urgently needed in clinical practice.
Product: Human Phosphoacetylglucosamine mutase (PGM3) ELISA Kit
Pub Date：2025-06-10 IF: 8.300
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