Recombinant Human Geminin (GMNN) Protein

Geminin was originally identified as an inhibitor of DNA replication and substrate of the anaphase promoting complex (APC). Coincidentally, geminin was also shown to expand the neural plate in the developing Xenopus embryo. Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
 

Reconstitute in PBS or others.
 

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 

Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.
 

Lyophilized from 20 mM PB, 300 mM NaCl，pH 7.4
 

This product is for research use only, not for diagnostic or therapeutic use.